Mendelian randomization analysis demonstrates that low vitamin D is unlikely causative for pediatric asthma
نویسندگان
چکیده
منابع مشابه
Vitamin D and mortality: a Mendelian randomization study.
BACKGROUND Decreased circulating 25-hydroxy-vitamin D (25-OH-vitamin D) concentrations have been associated with mortality rates, but it is unclear whether this association is causal. We performed a Mendelian randomization study and analyzed whether 3 common single-nucleotide polymorphisms (SNPs) associated with 25-OH-vitamin D concentrations are causal for mortality rates. METHODS Genotypes ...
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Vitamin D deficiency is widely prevalent and has been associated with many diseases. It has been suggested that vitamin D has effects on the immune system and inhibits inflammation. The aim of our study was to investigate whether vitamin D has an inhibitory effect on systemic inflammation by assessing the association between serum levels of vitamin D and C-reactive protein. We studied the assoc...
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doi: 10.1093/ije/dyw265 Commentary: Mendelian randomization analysis identifies circulating vitamin D as a causal risk factor for ovarian cancer Caroline J Bull*, James Yarmolinsky and Kaitlin H Wade School of Social and Community Medicine, University of Bristol, Bristol, UK, MRC/University of Bristol Integrative Epidemiology Unit, University of Bristol, Bristol, UK and IGFs and Metabolic Endoc...
متن کاملMendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk
OBJECTIVE We sought to estimate the causal effect of low serum 25(OH)D on multiple sclerosis (MS) susceptibility that is not confounded by environmental or lifestyle factors or subject to reverse causality. METHODS We conducted mendelian randomization (MR) analyses using an instrumental variable (IV) comprising 3 single nucleotide polymorphisms found to be associated with serum 25(OH)D levels...
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BACKGROUND Vitamin D deficiency is associated with nonalcoholic fatty liver disease (NAFLD) in many cross-sectional studies. However, the causality between them has not been established. We used bi-directional mendelian randomization (MR) analysis to explore the causal relationship between 25-hydroxyvitamin D [25(OH)D] and NAFLD. METHODS 9182 participants were included from a survey in East C...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2016
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2016.06.056